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Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 on the active metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 towards the active metabolite temazepam.Clients must be counseled to consider this drug ideal just before they enter into bed and only when they are capable of stay in bed an entire night time (seven-8 hours) right